Influence of Risk Factors for Male Infertility on Sperm Protein Composition.

ABSTRACT: Male infertility is a common health problem that can be influenced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. These effects have been largely demonstrated on sperm parameters (e.g., motility, numeration, vitality, DNA integrity). In addition, several studies showed the deregulation of sperm proteins in relation to some of these factors. This review inventories the literature related to the identification of sperm proteins showing abundance variations in response to the four risk factors for male infertility that are the most investigated in this context: obesity, diabetes, tobacco smoking, and exposure to bisphenol-A (BPA). First, we provide an overview of the techniques used to identify deregulated proteins. Then, we summ

SUBMITTER: Bisconti M 

PROVIDER: S-EPMC8658491 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature