Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart.

ABSTRACT: In recent years, computational fluid dynamics (CFD) has been extensively used in biomedical research on heart diseases due to its non-invasiveness and relative ease of use in predicting flow patterns inside the cardiovascular system. In this study, a modeling approach involving CFD simulations was employed to study hemodynamics inside the left ventricle (LV) of a human heart affected by a mitral paravalvular leak (PVL). A simplified LV geometry with four PVL variants that varied in shape and size was studied. Predicted blood flow parameters, mainly velocity and shear stress distributions, were used as indicators of how presence of PVLs correlates with risk and severity of hemolysis. The calculations performed in the study showed a high risk of hemolysis in all analyzed cases, with the maxi

SUBMITTER: Wojtas K 

PROVIDER: S-EPMC8658524 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature