Effects of Hochuekkito, a traditional Japanese medicine (Kampo), on reproduction of aging female mice.

ABSTRACT:

Purpose

To determine the potentials of Hochuekkito (HET) treatment for aging infertility.

Methods

Mice at 36 weeks of age were fed without (control, n = 40) or with low (100 mg/kg/day, n = 24) and high (1000 mg/kg/day, n = 38) doses of HET for 12 weeks. Aging animals at 48 weeks of age were used for in vitro fertilization-embryo transfer (IVF-ET), and their ovaries were subjected to histological and quantitative inflammation analyses.

Results

HET administration decreased transcript levels of ovarian inflammatory markers, interleukin 6 (IL-6), IL-1β, tumor necrosis factor (TNF)-α, and interferon-gamma (IFN-γ) but suppressed ovulation rates and the number of ovulated oocytes in aging mice. Furthermore, HET treatment decreased the rates of oocytes ma

SUBMITTER: Vo KCT 

PROVIDER: S-EPMC8658873 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature