Organometallic small molecule kinase inhibitors - direct incorporation of Re and 99mTc into Opaganib®.

ABSTRACT: [(η5-Cp)Re^I(CO)₃] was incorporated into the kinase inhibitor Opaganib®. The resulting bioorganometallic complex showed a similar anti-cancer activity to Opaganib® against PC-3 cancer cells. The IC₅₀ value for the kinase SK2 is 30x higher than that of Opaganib®. The 99mTc homologue was synthesized, completing a matched-pair for molecular theranostics.

SUBMITTER: Lengacher R 

PROVIDER: S-EPMC8658909 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature