Piano-Stool Ruthenium(II) Complexes with Delayed Cytotoxic Activity: Origin of the Lag Time.

ABSTRACT: We have recently reported a series of piano-stool ruthenium(II) complexes of the general formula [RuCl₂(η⁶-arene)(P(1-pyrenyl)R²R³)] showing excellent cytotoxic activities (particularly when R² = R³ = methyl). In the present study, new members of this family of compounds have been prepared with the objective to investigate the effect of the steric hindrance of a bulky phosphane ligand, namely diisopropyl(1-pyrenyl)phosphane (L), on exchange reactions involving the coordinated halides (X = Cl, I). Two η⁶-arene rings were used, i.e. η⁶-methyl benzoate (mba) and η⁶-p-cymene (p-cym), and four complexes were synthesized, namely [RuCl₂(mba)(L)] (1_C

SUBMITTER: Rafols L 

PROVIDER: S-EPMC8659375 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature