Association between temporal summation and conditioned pain modulation in chronic low back pain: baseline results from 2 clinical trials.

ABSTRACT:

Introduction

Temporal summation (TS) and conditioned pain modulation (CPM) represent different aspects of central pain processing. Their relationship and differential performance within distinct body locations are not well understood.

Objectives

To examine the association between TS and CPM in chronic low back pain and the influence of testing location on this relationship.

Methods

We analyzed baseline data from 2 clinical trials on participants with chronic low back pain (n = 264; 47.3% female; mean age = 41 years, SD = 12; mean pain = 5.3/10, SD = 1.4). Measures used included questionnaires assessing pain and negative affect, phasic thermal TS at the hand (thenar) and the lower back (lumbar), followed by CPM that included a thermal testing stimulus (Heat-6, t

SUBMITTER: Kong JT 

PROVIDER: S-EPMC8660006 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature