Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata.

ABSTRACT: Fungal infections are a growing medical concern, in part due to increased resistance to one or multiple antifungal drugs. However, the evolutionary processes underpinning the acquisition of antifungal drug resistance are poorly understood. Here, we used experimental microevolution to study the adaptation of the yeast pathogen Candida glabrata to fluconazole and anidulafungin, two widely used antifungal drugs with different modes of action. Our results show widespread ability of rapid adaptation to one or both drugs. Resistance, including multidrug resistance, is often acquired at moderate fitness costs and mediated by mutations in a limited set of genes that are recurrently and specifically mutated in strains adapted to each of the drugs. Importantly, we uncover a dual role of ERG3 mutatio

SUBMITTER: Ksiezopolska E 

PROVIDER: S-EPMC8660101 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature