Synthetic aperture interference light (SAIL) microscopy for high-throughput label-free imaging.

ABSTRACT: Quantitative phase imaging (QPI) is a valuable label-free modality that has gained significant interest due to its wide potentials, from basic biology to clinical applications. Most existing QPI systems measure microscopic objects via interferometry or nonlinear iterative phase reconstructions from intensity measurements. However, all imaging systems compromise spatial resolution for the field of view and vice versa, i.e., suffer from a limited space bandwidth product. Current solutions to this problem involve computational phase retrieval algorithms, which are time-consuming and often suffer from convergence problems. In this article, we presented synthetic aperture interference light (SAIL) microscopy as a solution for high-resolution, wide field of view QPI. The proposed approach employ

SUBMITTER: Hu C 

PROVIDER: S-EPMC8660142 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature