Tianxiangdan Improves Coronary Microvascular Dysfunction in Rats by Inhibiting Microvascular Inflammation via Nrf2 Activation.

ABSTRACT:

Background

Tianxiangdan (TXD) is used in traditional Chinese medicine because of its therapeutic and preventive effects in the treatment of coronary heart disease. However, the underlying mechanism of TXD in coronary microvascular disease (CMD) remains unclear.

Methods

A rat model of CMD was developed to study the mechanism of TXD activity. Sodium laurate was injected into the left ventricle of Sprague-Dawley rats to induce CMD. The rats were divided into six groups: a sham-operated (sham) group, an untreated CMD group, a low-dose TXD group (0.81 g·kg^-1·d^-1), a mid-dose TXD (TXD-M) group (1.62 g·kg^-1·d^-1), a high-dose TXD (TXD-H) group (3.24 g·kg^-1·d^-1), and a nicorandil (NCR) group (1.35 mg·kg^-1·d<

SUBMITTER: Sawuer G 

PROVIDER: S-EPMC8660204 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature