Frequencies of CYP2B6^∗4,^∗5, and ^∗6 Alleles within an Iranian Population (Mazandaran).

ABSTRACT:

Background

The human CYP2B subfamily consists of one functional gene (CYP2B6) and one pseudogene (CYP2B7P). Cytochrome P450 2B6 (CYP2B6) is a highly polymorphic enzyme that shows marked interindividual and interethnic variations. Currently, 38 alleles have been described, and some of the allelic variants have been associated with low enzyme activity. The aim of this study was to investigate the frequencies of CYP2B6^∗4, CYP2B6^∗5, and CYP2B6^∗6 alleles in the Mazani ethnic group among Iranian Population.

Methods

The study was conducted in 289 unrelated healthy volunteers. DNA was extracted from peripheral blood and analyzed by the PCR-RFLP protocol. The PCR product was digested with restriction enzymes and then separated using agarose gel electr

SUBMITTER: Hashemi-Soteh MB 

PROVIDER: S-EPMC8660211 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature