Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial.

ABSTRACT:

Introduction

Aging is characterized by the progressive loss of physiological capacity. Changes in gene expression can alter activity in defined age-related molecular pathways leading to cellular aging and increased aging disease susceptibility. The aim of the current study was to evaluate whether hyperbaric oxygen therapy (HBOT) affects gene expression in normal, non-pathological, aging adults.

Methods

Thirty-five healthy independently living adults, aged 64 and older, were enrolled to receive 60 daily HBOT exposures. Whole blood samples were collected at baseline, at the 30th and 60th HBOT session, and 1-2 weeks following the last session. Differential gene expression analysis was performed.

Results

Following 60 sessions of HBOT, 1342 genes and 570 genes were differe

SUBMITTER: Hadanny A 

PROVIDER: S-EPMC8660606 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature