BMPR2 promoter methylation and its expression in valvular heart disease complicated with pulmonary artery hypertension.

ABSTRACT: Valvular heart disease (VHD) is a common heart disease that affects blood flow. It usually requires heart surgery. Valvular heart disease complicated with pulmonary artery hypertension (VHD-PAH) may be lethal due to heart failure that results from increased heart burden. It is important for these patients to seek early treatment in order to minimize the heart damage. However, there is no reliable diagnosis method in VHD. In this study, we found DNA methylation was increased at the promoter of BMPR2 gene in the VHD patients compared with the healthy controls. This finding was confirmed by an independent cohort study of VHD patients and healthy controls. In addition, BMPR2 mRNA levels were reduced in the plasma of the VHD patients. There is strong correlation between BMPR2</

SUBMITTER: Li N 

PROVIDER: S-EPMC8660616 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature