Incidence of invasive Group B Streptococcal infection and the risk of infant death and cerebral palsy: a Norwegian Cohort Study.

ABSTRACT:

Background

Group B Streptococcus (GBS) is the leading cause of invasive neonatal infection worldwide. In high-income countries mortality rates are 4-10%, and among survivors of GBS meningitis 30-50% have neurodevelopmental impairments. We hypothesized that invasive GBS infection was associated with increased risk of infant mortality and cerebral palsy (CP).

Methods

All children born alive in Norway during 1996-2012 were included. Data were collected from three national registers. Invasive GBS infection during infancy was categorized into early-onset disease (EOD), late-onset disease (LOD), and very late-onset disease (VLOD). Primary outcomes were infant mortality and CP.

Results

Invasive GBS infection was diagnosed in 625 children (incidence: 0.62 per 1000 live births

SUBMITTER: Mynarek M 

PROVIDER: S-EPMC8660635 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature