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Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events.
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ABSTRACT:
SUBMITTER: Siddiqui MK
PROVIDER: S-EPMC8660745 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events.
Diabetologia 20210925 1
<h4>Aims/hypothesis</h4>Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has an independent prognostic association with major coronary events (MCE). However, no study has investigated whether type 2 diabetes status modifies the effect of Lp-PLA2 activity or inhibition on the risk of MCE. We investigate the interaction between diabetes status and Lp-PLA2 activity with risk of MCE. Subsequently, we test the resulting hypothesis that diabetes status will play a role in modifying the effic ...[more]