Constructing gene regulatory networks using epigenetic data.

ABSTRACT: The biological processes that drive cellular function can be represented by a complex network of interactions between regulators (transcription factors) and their targets (genes). A cell's epigenetic state plays an important role in mediating these interactions, primarily by influencing chromatin accessibility. However, how to effectively use epigenetic data when constructing a gene regulatory network remains an open question. Almost all existing network reconstruction approaches focus on estimating transcription factor to gene connections using transcriptomic data. In contrast, computational approaches for analyzing epigenetic data generally focus on improving transcription factor binding site predictions rather than deducing regulatory network relationships. We bridged this gap by develo

SUBMITTER: Sonawane AR 

PROVIDER: S-EPMC8660777 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature