Intracellular thermometry uncovers spontaneous thermogenesis and associated thermal signaling.

ABSTRACT: Conventional thermal biology has elucidated the physiological function of temperature homeostasis through spontaneous thermogenesis and responses to variations in environmental temperature in organisms. In addition to research on individual physiological phenomena, the molecular mechanisms of fever and physiological events such as temperature-dependent sex determination have been intensively addressed. Thermosensitive biomacromolecules such as heat shock proteins (HSPs) and transient receptor potential (TRP) channels were systematically identified, and their sophisticated functions were clarified. Complementarily, recent progress in intracellular thermometry has opened new research fields in thermal biology. High-resolution intracellular temperature mapping has uncovered thermogenic organe

SUBMITTER: Okabe K 

PROVIDER: S-EPMC8660847 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature