Sex-specific effects of aging on humoral immune responses to repeated influenza vaccination in older adults.

ABSTRACT: Older adults (≥65 years of age) bear a significant burden of severe disease and mortality associated with influenza, despite relatively high annual vaccination coverage and substantial pre-existing immunity to influenza. To test the hypothesis that host factors, including age and sex, play a role in determining the effect of repeated vaccination and levels of pre-existing humoral immunity to influenza, we evaluated pre- and post-vaccination strain-specific hemagglutination inhibition (HAI) titers in adults over 75 years of age who received a high-dose influenza vaccine in at least four out of six influenza seasons. Pre-vaccination titers, rather than host factors and repeated vaccination were significantly associated with post-vaccination HAI titer outcomes, and displayed an age-by-sex int

SUBMITTER: Shapiro JR 

PROVIDER: S-EPMC8660902 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature