Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma.

ABSTRACT:

Background

Infants with bronchiolitis are at increased risk for developing asthma. Growing evidence suggests bronchiolitis is a heterogeneous condition.

Objectives

We sought to identify biologically distinct subgroups based on the metabolome signatures (metabotypes) in infants with severe bronchiolitis and to examine the longitudinal relationships of metabotypes with asthma development.

Methods

In a multicenter prospective cohort study of infants (age, <12 months) hospitalized for bronchiolitis, the nasopharyngeal airway metabolome was profiled at hospitalization. Using a clustering approach, this study identified mutually exclusive metabotypes. This study also examined their longitudinal association with the risk of developing asthma by 5 years of age.

Results

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC8660920 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature