Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.

ABSTRACT: Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor outcomes, and is associated with a greater degree of cognitive impairment and depressive symptoms, compared to subjects without psychosis (AD - P). Although the estimated heritability of AD + P is 61%, genetic sources of risk are unknown. We report a genome-wide meta-analysis of 12,317 AD subjects, 5445 AD + P. Results showed common genetic variation accounted for a significant portion of heritability. Two loci, one in ENPP6 (rs9994623, O.R. (95%CI) 1.16 (1.10, 1.22), p = 1.26 × 10^-8) and one spanning the 3'-UTR of an alternatively spliced transcript of SUMF1 (rs201

SUBMITTER: DeMichele-Sweet MAA 

PROVIDER: S-EPMC8660923 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature