A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy.

ABSTRACT: The enzyme-mediated elevation of reactive oxygen species (ROS) at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer treatment. Herein, we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti₃C₂ nanosheets for combined tumor enzyme dynamic therapy (EDT), phototherapy and deoxygenation-activated chemotherapy. Briefly, glucose oxidase (GOX) and chloroperoxidase (CPO) were chemically conjugated onto Ti₃C₂ nanosheets, where the deoxygenation-activated drug tirapazamine (TPZ) was also loaded, and the Ti₃C₂-GOX-CPO/TPZ (TGCT) was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47 (m_eTGCT). Due to biomimetic membran

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8660948 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature