Acute lung injury secondary to hydrochloric acid instillation induces small airway hyperresponsiveness.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure characterized by altered lung mechanics and poor oxygenation. Bronchial hyperresponsiveness has been reported in ARDS survivors and animal models of acute lung injury. Whether this hyperreactivity occurs at the small airways or not is unknown.

Objective

To determine ex-vivo small airway reactivity in a rat model of acute lung injury (ALI) by hydrochloric acid (HCl) instillation.

Methods

Twelve anesthetized rats were connected to mechanical ventilation for 4-hour, and randomly allocated to either ALI group (HCl intratracheal instillation; n=6) or Sham (intratracheal instillation of 0.9% NaCl; n=6). Oxygenation was assessed by arterial blood gases. After euthanasia, tiss

SUBMITTER: Basoalto R 

PROVIDER: S-EPMC8661233 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature