Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells.

ABSTRACT: Dopamine signaling has numerous roles during brain development. In addition, alterations in dopamine signaling may be also involved in the pathophysiology of psychiatric disorders. Neurodevelopment is modulated in multiple steps by reactive oxygen species (ROS), byproducts of oxidative metabolism that are signaling factors involved in proliferation, differentiation, and migration. Hexokinase (HK), when associated with the mitochondria (mt-HK), is a potent modulator of the generation of mitochondrial ROS in the brain. In the present study, we investigated whether dopamine could affect both the activity and redox function of mt-HK in human neural progenitor cells (NPCs). We found that dopamine signaling via D1R decreases mt-HK activity and impairs ROS modulation, which is followed by an expr

SUBMITTER: Assis-de-Lemos G 

PROVIDER: S-EPMC8661505 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature