Orally administered Bi₂S₃@SiO₂ core-shell nanomaterials as gastrointestinal contrast agents and their influence on gut microbiota.

ABSTRACT: Effective and safe contrast agents for X-ray computed tomography (CT) imaging of the gastrointestinal (GI) tract are quite desirable for realizing high diagnostic accuracy and low toxicity in the clinic. Herein, we synthesize a series of silica-coated bismuth sulfide core-shell nanomaterials (Bi₂S₃@SiO₂) of various sizes and systematically study their GI CT contrast performance and potential toxic effects in comparison with those of barium sulfate (BaSO₄) in mice. The in vivo experimental results suggest that these Bi₂S₃@SiO₂ core-shell nanomaterials display superior CT contrast performance and higher elimination efficacy than BaSO₄ by single-dose exposure manner (10 ​mg/kg Bi element/b.w. for Bi

SUBMITTER: Chen R 

PROVIDER: S-EPMC8661703 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature