Elucidating important structural features for the binding affinity of spike - SARS-CoV-2 neutralizing antibody complexes.

ABSTRACT: The coronavirus disease 2019 (COVID-19) has affected the lives of millions of people around the world. In an effort to develop therapeutic interventions and control the pandemic, scientists have isolated several neutralizing antibodies against SARS-CoV-2 from the vaccinated and convalescent individuals. These antibodies can be explored further to understand SARS-CoV-2 specific antigen-antibody interactions and biophysical parameters related to binding affinity, which can be utilized to engineer more potent antibodies for current and emerging SARS-CoV-2 variants. In the present study, we have analyzed the interface between spike protein of SARS-CoV-2 and neutralizing antibodies in terms of amino acid residue propensity, pair preference, and atomic interaction energy. We observed that Tyr re

SUBMITTER: Sharma D 

PROVIDER: S-EPMC8661754 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature