Epigenetic Regulation of miR-92a and TET2 and Their Association in Non-Hodgkin Lymphoma.

ABSTRACT: MicroRNAs (miRNAs) are well known for their ability to regulate the expression of specific target genes through degradation or inhibition of translation of the target mRNA. In various cancers, miRNAs regulate gene expression by altering the epigenetic status of candidate genes that are implicated in various difficult to treat haematological malignancies such as non-Hodgkin lymphoma by acting as either oncogenes or tumour suppressor genes. Cellular and circulating miRNA biomarkers could also be directly utilised as disease markers for diagnosis and monitoring of non-Hodgkin lymphoma (NHL); however, the role of DNA methylation in miRNA expression regulation in NHL requires further scientific inquiry. In this study, we investigated the methylation levels of CpGs in CpG islands spanning the pr

SUBMITTER: Elliott EK 

PROVIDER: S-EPMC8661906 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature