Molecular evolutionary characteristics of SARS-CoV-2 emerging in the United States.

ABSTRACT: SARS-CoV-2 is a newly discovered beta coronavirus at the end of 2019, which is highly pathogenic and poses a serious threat to human health. In this paper, 1875 SARS-CoV-2 whole genome sequences and the sequence coding spike protein (S gene) sampled from the United States were used for bioinformatics analysis to study the molecular evolutionary characteristics of its genome and spike protein. The MCMC method was used to calculate the evolution rate of the whole genome sequence and the nucleotide mutation rate of the S gene. The results showed that the nucleotide mutation rate of the whole genome was 6.677 × 10^-4 substitution per site per year, and the nucleotide mutation rate of the S gene was 8.066 × 10^-4 substitution per site per year, which was at a medium level co

SUBMITTER: Wang S 

PROVIDER: S-EPMC8662038 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature