Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells.

ABSTRACT: Numerous studies have demonstrated that overexpression or aberrant expression of the HMGI(Y) family of architectural transcription factors is frequently associated with both neoplastic transformation of cells and metastatic tumor progression. Little is known, however, about the molecular roles played by the HMGI(Y) proteins in these events. Here we report that human breast epithelial cells harboring tetracycline-regulated HMGI(Y) transgenes acquire the ability to form both primary and metastatic tumors in nude mice only when the transgenes are actively expressed. Unexpectedly, the HMG-Y, rather than the HMG-I, isoform of these proteins is the most effective elicitor of both neoplastic transformation and metastatic progression in vivo. Furthermore, expression of either antisense or dominant

SUBMITTER: Reeves R 

PROVIDER: S-EPMC86623 | biostudies-literature | 2001 Jan

REPOSITORIES: biostudies-literature