Difference in Analgesic Effects of Repetitive Transcranial Magnetic Stimulation According to the Site of Pain.

ABSTRACT: High-frequency repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex for neuropathic pain has been shown to be effective, according to systematic reviews and therapeutic guidelines. However, our large, rigorous, investigator-initiated, registration-directed clinical trial failed to show a positive primary outcome, and its subgroup analysis suggested that the analgesic effect varied according to the site of pain. The aim of this study was to investigate the differences in analgesic effects of rTMS for neuropathic pain between different pain sites by reviewing our previous clinical trials. We included three clinical trials in this mini meta-analysis: a multicenter randomized controlled trial at seven hospitals (N = 64), an investigator-initiated registration-

SUBMITTER: Mori N 

PROVIDER: S-EPMC8662379 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature