Succinate dehydrogenase 5 regulates lung cancer metastasis by reprogramming glucose metabolism.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death globally, with many of these patients also suffering from diabetes. Previous studies have shown that diabetes may contribute to cancer progression through hyperglycemia. However, the underlying mechanism remains largely unknown. This study aimed to investigate the role of succinate dehydrogenase 5 (SDH5), an enzyme required for assembling respiratory complex II in lung cancer patients with diabetes.

Methods

The expression levels of SDH5 in patient plasma and tissue were determined by RT-qPCR. Western blotting, immunofluorescence (IF), and immunohistology (IHC) were used to examine protein expression. Migration and invasion assays were performed using Transwell assays. Reactive oxygen species (ROS) production

SUBMITTER: Li J 

PROVIDER: S-EPMC8662473 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature