Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma.

ABSTRACT:

Purpose

To investigate modeling of the focal visual field (VF) loss by combining structural measurements and vascular measurements in eyes with early primary open-angle glaucoma (POAG).

Methods

In this cross-sectional study, subjects with early glaucoma (VF mean deviation, ≥-6 dB) underwent optical coherence tomography (OCT) imaging, optical coherence tomography angiography (OCTA) imaging, and Humphrey 24-2 VF tests. Capillary perfusion densities (CPDs) were calculated after the removal of large vessels in the OCTA images. Focal associations between VF losses at the individual VF test locations, circumpapillary retinal nerve fiber layer (RNFL) thickness measurements from OCT, and CPDs were determined using nerve fiber trajectory tracings. Linear mixed models were used to mod

SUBMITTER: Wong D 

PROVIDER: S-EPMC8662568 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature