Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation.

ABSTRACT: Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

SUBMITTER: Perez JM 

PROVIDER: S-EPMC8662621 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature