Increased Ratio of CD14⁺⁺CD80⁺ Cells/CD14⁺⁺CD163⁺ Cells in the Infrapatellar Fat Pad of End-Stage Arthropathy Patients.

ABSTRACT:

Objectives

This study sought to identify the ratio of M1/M2 cells in the infrapatellar fat pads (IFP) and subcutaneous fat tissues (SC) of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. The clinical features of OA and RA patients treated with or without biological disease-modifying anti-rheumatic drugs (bDMARDs) were also assessed.

Methods

IFP and SC were collected from patients with OA and RA who are undergoing total knee arthroplasty (TKA). CD14-positive cells were then isolated from these samples. Flow cytometry was used to determine the number of CD14⁺⁺CD80⁺ cells and CD14⁺⁺CD163⁺ cells. The expression levels of lipid transcription factors, such as sterol regulatory element-binding protein 1 (SREBP1) and liver X re

SUBMITTER: Ma S 

PROVIDER: S-EPMC8662627 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature