Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource.

ABSTRACT: Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome data sets from natural populations of this species have been published over the last years. A major challenge is the integration of disparate data sets, often generated using different sequencing technologies and bioinformatic pipelines, which hampers our ability to address questions about the evolution of this species. Here we address these issues by developing a bioinformatics pipeline that maps pooled sequencing (Pool-Seq) reads from D. melanogaster to a hologenome consisting of fly and symbiont genomes and estimates allele frequencies using either a heuristic (PoolSNP) or a probabilistic variant caller (SNAPE-pooled). We use this pipeline to generate the largest data rep

SUBMITTER: Kapun M 

PROVIDER: S-EPMC8662648 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature