Role of Human Bocavirus Respiratory Tract Infection in Hematopoietic Cell Transplant Recipients.

ABSTRACT:

Background

Limited data exist regarding the impact of human bocavirus (BoV) in hematopoietic cell transplant (HCT) recipients.

Methods

In a longitudinal surveillance study among allogeneic HCT recipients, pre-HCT and weekly post-HCT nasal washes and symptom surveys were collected through day 100, then at least every 3 months through 1 year post-HCT at the Fred Hutchinson Cancer Research Center (2005-2010). Samples were tested by multiplex semiquantitative polymerase chain reaction (PCR) for 12 viruses. Plasma samples from BoV + subjects were analyzed by PCR. Separately, we conducted a retrospective review of HCT recipients with BoV detected in lower respiratory tract specimens.

Results

Among 51 children and 420 adults in the prospective cohort, 21 distinct BoV respira

SUBMITTER: Ogimi C 

PROVIDER: S-EPMC8662760 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature