Household Transmission of Carbapenemase-producing Enterobacterales in Ontario, Canada.

ABSTRACT:

Background

Data on household transmission of carbapenemase-producing Enterobacterales (CPE) remain limited. We studied risk of CPE household co-colonization and transmission in Ontario, Canada.

Methods

We enrolled CPE index cases (identified via population-based surveillance from January 2015 to October 2018) and their household contacts. At months 0, 3, 6, 9, and 12, participants provided rectal and groin swabs. Swabs were cultured for CPE until September 2017, when direct polymerase chain reaction (PCR; with culture of specimens if a carbapenemase gene was detected) replaced culture. CPE risk factor data were collected by interview and combined with isolate whole-genome sequencing to determine likelihood of household transmission. Risk factors for household contact coloniz

SUBMITTER: Jamal AJ 

PROVIDER: S-EPMC8662791 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature