Estimating the transmission advantage of the D614G mutant strain of SARS-CoV-2, December 2019 to June 2020.

ABSTRACT: IntroductionThe SARS-CoV-2 lineages carrying the amino acid change D614G have become the dominant variants in the global COVID-19 pandemic. By June 2021, all the emerging variants of concern carried the D614G mutation. The rapid spread of the G614 mutant suggests that it may have a transmission advantage over the D614 wildtype.AimOur objective was to estimate the transmission advantage of D614G by integrating phylogenetic and epidemiological analysis.MethodsWe assume that the mutation D614G was the only site of interest which characterised the two cocirculating virus strains by June 2020, but their differential transmissibility might be attributable to a combination of D614G and other mutations. We define the fitness of G614 as the ratio of the basic reproduction number of the strain with

SUBMITTER: Leung K 

PROVIDER: S-EPMC8662801 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature