Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis.

ABSTRACT:

Background

Since the 1990s, there have been a lot of research on single-nucleotide polymorphism (SNP) and different diseases, including many studies on 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism and essential hypertension (EH). Nevertheless, their conclusions were controversial. So far, six previous meta-analyses discussed the internal relationship between the MTHFR polymorphism and EH, respectively. However, they did not evaluate the credibility of the positive associations. To build on previous meta-analyses, we updated the literature by including previously included papers as well as nine new articles, improved the inclusion criteria by also considering the quality of the papers, and applied new statistical techniques to assess the observed assoc

SUBMITTER: Meng H 

PROVIDER: S-EPMC8662810 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature