Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage.

ABSTRACT:

Background

Cognitive impairment and depressive symptoms are highly prevalent after Intracerebral Hemorrhage (ICH). We leveraged Latent Profile Analysis (LPA) to identify profiles for cognitive decline and depression onset after ICH. We also investigated differences in clinical, genetic and neuroimaging characteristics across patients' profiles.

Methods

We analyzed data from the ICH study conducted at Massachusetts General Hospital between January 1998 and December 2019. We collected information from electronical health records, follow-up interviews, CT and MRI imaging, and APOE genotype. We conducted LPA and multinomial logistic regression analyses to: 1) identify distinct profiles for cognitive decline and depression onset after ICH; 2) identify clinical, neuroimaging and g

SUBMITTER: Keins S 

PROVIDER: S-EPMC8662844 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature