Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort.

ABSTRACT:

Background

Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2).

Methods

To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested with

SUBMITTER: His M 

PROVIDER: S-EPMC8662901 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature