Plasma Soluble CD14 Subtype Levels Are Associated With Clinical Outcomes in Critically Ill Subjects With Coronavirus Disease 2019.

ABSTRACT:

Importance

In bacterial sepsis, CD14 and its N-terminal fragment (soluble CD14 subtype, "Presepsin") have been characterized as markers of innate immune responses and emerging evidence has linked both to coronavirus disease 2019 pathophysiology.

Objectives

Our aim was to determine the relationship between the soluble form of CD14 and soluble CD14 subtype plasma levels, coronavirus disease 2019 status, and coronavirus disease 2019-related outcomes.

Design

A prospective cohort study.

Setting

ICUs in three tertiary hospitals in Seattle, WA.

Participants

Two-hundred four critically ill patients under investigation for coronavirus disease 2019.

Main outcomes and measures

We measured plasma soluble CD14 and soluble CD14 subtype levels in samples collect

SUBMITTER: Mabrey FL 

PROVIDER: S-EPMC8663850 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature