Early intervention of acute liver injury related to venlafaxine: A case report.

ABSTRACT:

Rationale

Drug-induced liver injury (DILI) is the leading cause of acute liver injury (ALI), market withdrawal of a drug, and rejection of applications for marketing licenses. The incidence of DILI is very low, with a value between 1 and 19 per 100,000 patient years. All antidepressants may induce DILI even at low therapeutic doses. In this report, we present a case of ALI after venlafaxine administration.

Patient concerns

A 27-year-old Chinese Han woman was admitted for depression. Several serum liver function indices in this patient were abnormal after antidepressant treatment. The Roussel Uclaf Causality Assessment Method (RUCAM) causality assessment score was 8, and the R value was 31.18.

Diagnoses

The patient was diagnosed with hepatocellular ALI, which was deriv

SUBMITTER: Fang L 

PROVIDER: S-EPMC8663904 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature