Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions.

ABSTRACT: Autophagy is a critical metabolic process that supports homeostasis at a basal level and is dynamically regulated in response to various physiological and pathological processes. Autophagy has some etiologic implications that support certain pathological processes due to alterations in the lysosomal-degradative pathway. Some of the conditions related to autophagy play key roles in highly relevant human diseases, e.g., cardiovascular diseases (15.5%), malignant and other neoplasms (9.4%), and neurodegenerative conditions (3.7%). Despite advances in the discovery of new strategies to treat these age-related diseases, autophagy has emerged as a therapeutic option after preclinical and clinical studies. Here, we discuss the pitfalls and success in regulating autophagy initiation and its lysoso

SUBMITTER: Martins WK 

PROVIDER: S-EPMC8663935 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature