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The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis.

ABSTRACT: [Figure: see text].

SUBMITTER: Cheng D

PROVIDER: S-EPMC8664259 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis.

Cheng Dan D Semmens Kevin K McManus Elizabeth E Chen Qingrong Q Meerzaman Daoud D Wang Xiantao X Hafner Markus M Lewis Brian A BA Takahashi Hidehisa H Devaiah Ballachanda N BN Gegonne Anne A Singer Dinah S DS

Science advances 20211210 50

The TFIID component, TAF7, has been extensively characterized as essential for transcription and is critical for cell proliferation and differentiation. Here, we report that TAF7 is a previously unknown RNA chaperone that contributes to the regulation of protein synthesis. Mechanistically, TAF7 binds RNAs in the nucleus and delivers them to cytoplasmic polysomes. A broad spectrum of target RNA species, including the HIV-1 transactivation response element, binds TAF7 through consensus CUG motifs ...[more]

PMID: 34890234

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The Nuclear Transcription factor TAF7 is a Cytoplasmic RNA Chaperone

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