Altered neurochemistry in the anterior white matter of bipolar children and adolescents: a multivoxel ¹H MRS study.

ABSTRACT: Abnormalities within frontal lobe gray and white matter of bipolar disorder (BD) patients have been consistently reported in adult and pediatric studies, yet little is known about the neurochemistry of the anterior white matter (AWM) in pediatric BD and how medication status may affect it. The present cross-sectional 3T ¹H MRS study is the first to use a multivoxel approach to study the AWM of BD youth. Absolute metabolite levels from four bilateral AWM voxels were collected from 49 subjects between the ages of 8 and 18 (25 healthy controls (HC); 24 BD) and quantified. Our study found BD subjects to have lower levels of N-acetylaspartate (NAA) and glycerophosphocholine plus phosphocholine (GPC + PC), metabolites that are markers of neuronal viability and phospholipid metabolism

SUBMITTER: Tannous J 

PROVIDER: S-EPMC8664279 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature