The Effect of Buprenorphine on Human Immunodeficiency Virus Viral Suppression.

ABSTRACT:

Background

Opioid use is prevalent among people living with human immunodeficiency virus (HIV; PLWH) and adversely affects HIV outcomes. We assessed the effect of buprenorphine (BUP) initiation on subsequent HIV viral loads.

Methods

We identified PLWH from the Johns Hopkins HIV Clinical Cohort who initiated BUP between 2002 and 2017. Poisson regression with robust variance was used to estimate the prevalence of viral suppression (<200 copies/mL) before and after BUP initiation. We matched individuals who initiated BUP with controls based on viral load measurement dates and used prior event rate ratio (PERR) methods to estimate the effect of BUP initiation on viral suppression. PERR methods account for unmeasured confounders.

Results

We identified 279 PLWH who initiate

SUBMITTER: Kim J 

PROVIDER: S-EPMC8664419 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature