Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing.

ABSTRACT: Protein kinases and phosphatases constitute a large family of conserved enzymes that control a variety of biological processes by regulating the phosphorylation state of target proteins. They play fundamental regulatory roles during cell cycle progression and signaling, among other key aspects of multicellular development. The complement of protein kinases and phosphatases includes approximately 326 members in Drosophila, and they have been the subject of several functional screens searching for novel components of signaling pathways and regulators of cell division and survival. These approaches have been carried out mostly in cell cultures using RNA interference to evaluate the contribution of each protein in different functional assays and have contributed significantly to assign specifi

SUBMITTER: Ostale CM 

PROVIDER: S-EPMC8664455 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature