Epidemiological Impact and Cost-Effectiveness of Varicella Vaccination Strategies in the United Kingdom.

ABSTRACT:

Background

Despite the burden of varicella, there is no universal varicella vaccination (UVV) program in the United Kingdom (UK) due to concerns that it could increase herpes zoster (HZ) incidence. We assessed the cost-utility of a first-dose monovalent (varicella [V]) or quadrivalent (measles-mumps-rubella-varicella [MMRV]) followed by a second-dose MMRV UVV program. GSK and MSD varicella-containing vaccines (VCVs) were considered.

Methods

Dynamic transmission and cost-effectiveness models were adapted to the UK. Outcomes measured included varicella and HZ incidences and the incremental cost-utility ratio (ICURs) over a lifetime horizon. Payer and societal perspectives were evaluated.

Results

The impact of V-MMRV and MMRV-MMRV UVV programs on varicella incidence was

SUBMITTER: Akpo EIH 

PROVIDER: S-EPMC8664478 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature