Sporadic occurrence of recent selective sweeps from standing variation in humans as revealed by an approximate Bayesian computation approach.

ABSTRACT: During their dispersals over the last 100,000 years, modern humans have been exposed to a large variety of environments, resulting in genetic adaptation. While genome-wide scans for the footprints of positive Darwinian selection have increased knowledge of genes and functions potentially involved in human local adaptation, they have globally produced evidence of a limited contribution of selective sweeps in humans. Conversely, studies based on machine learning algorithms suggest that recent sweeps from standing variation are widespread in humans, an observation that has been recently questioned. Here, we sought to formally quantify the number of recent selective sweeps in humans, by leveraging approximate Bayesian computation and whole-genome sequence data. Our computer simulations reveale

SUBMITTER: Laval G 

PROVIDER: S-EPMC8664576 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature