PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait.

ABSTRACT:

Background

Sickle cell trait (HbAS) protects against severe Plasmodium falciparum malaria but not against placental malaria (PM). In this study, P falciparum erythrocyte membrane protein (PfEMP1)-specific antibodies were measured in HbAA and HbAS Beninese pregnant women as a proxy of exposure to specific PfEMP1 variants.

Methods

Plasma samples collected at delivery from 338 HbAA and 63 HbAS women were used to measure immunoglobulin (Ig)G levels to 6 recombinant PfEMP1 proteins and 3 corresponding native proteins expressed on the infected erythrocyte (IE) surface. Immunoglobulin G-mediated inhibition of VAR2CSA⁺ IEs adhesion to chondroitin sulfate A (CSA) was also tested.

Results

Levels of PfEMP1-specific IgG were similar in the 2 groups, excep

SUBMITTER: Lopez-Perez M 

PROVIDER: S-EPMC8664683 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature