APOL1, Sickle Cell Trait, and CKD in the Jackson Heart Study.

ABSTRACT:

Rationale & objective

Apolipoprotein L1 (APOL1) high-risk variants are associated with an increased risk for chronic kidney disease (CKD) among African Americans. Less is known regarding the risk for the development of CKD and kidney failure (end-stage kidney disease [ESKD]) among African Americans with only 1 APOL1 risk variant or whether the risk is modified by sickle cell trait.

Study design

The Jackson Heart Study is a community-based longitudinal cohort study.

Setting & participants

Self-reported African Americans in the Jackson Heart Study (n = 5,306).

Exposures

APOL1 G1 and G2 genotypes and sickle cell trait.

Outcomes

Incident CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m²), albuminuria (urinary album

SUBMITTER: Young BA 

PROVIDER: S-EPMC8664705 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature